Gut Podcast

Transcriptional analysis of the intestinal mucosa of patients with ulcerative colitis in remission

In this podcast, Mairi McLean interviews Julián Panés and Azucena Salas, both from the Department of Gastroenterology, IDIBAPS, Hospital Clínic, CIBER-EHD in Barcelona, Spain. They disuse their recent article, looking at transcription in the intestinal mucosa of patients with ulcerative colitis.read the full article online: http://tinyurl.com/n3uy6d4

mTNF reverse signalling induced by TNFα antagonists involves a GDF-1 dependent pathway

Mairi McLean talks to Philip Rosenstiel, Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel, and Stefan Schreiber, University Hospital Schleswig-Holstein, Kiel, about their paper: mTNF reverse signalling induced by TNFα antagonists involves a GDF-1 dependent pathway: implications for Crohn’s disease http://bit.ly/11FU0Qw.

Endoscopic improvement of mucosal lesions in patients with ileocolonic Crohn’s disease

Mairi McLean, Gut’s education editor, talks to Xavier Hébuterne, Department of Gastroenterology and Nutrition, Archet Hospital, Nice, and Jean-Frédéric Colombel, Universite Lille Nord de France, about their paper: Endoscopic improvement of mucosal lesions in patients with moderate to severe ileocolonic Crohn’s disease following treatment with certolizumab pegol http://bit.ly/10dtab8.

Bowel cancer screening in England

Before the UK national bowel cancer screening programmes were implemented, a pilot was set-up in England to see if results from randomised controlled trials could be replicated in the general population. Gut has recently published findings from the third round of this.Co-author David Weller, Centre for Population Health Sciences–General Practice, University of Edinburgh, UK, talks to Gut’s associate editor William Grady about effectiveness of screening, uptake and its link to ethnicity, and the potential of different methods.See also:Performance measures in three rounds of the English bowel cancer screening pilot (http://tinyurl.com/afyj365)

PUFAS and neoplasms

Mairi McLean, Gut education editor, talks to Professor Mark Hull, Leeds Institute of Molecular Medicine, about his research into the action of polyunsaturated fatty acids on the formation of neoplams.See also:Omega-3 polyunsaturated fatty acids for the treatment and prevention of colorectal cancer (http://tinyurl.com/a7q8co4)

Cancer treatment induced gastrointestinal symptoms

In the UK chronic gastrointestinal symptoms after cancer therapies have a similar impact as IBD. However, in contrast to patients with IBD, most of these patients won’t see a gastroenterologist. In this month’s Gut Editor’s Choice the causes of these side effects of cancer treatment are discussed, as well as the benefits of investigation and treatment.In this podcast Mairi McLean, senior clinical lecturer and consultant in gastroenterology at the University of Aberdeen talks to some key stakeholders in this issue:Professor Sir Mike Richards, national clinical director for cancer and end of life care, Department of HealthJane Maher, chief medical officer for McMillian Cancer SupportJon Rhodes, professor of gastroenterology and president of the British Society of GastroenterologyJervoise Andeyev, consultant gastroenterologist in pelvic radiation disease at the Royal Marsden NHS Trust, LondonSee also:Practice guidance on the management of acute and chronic gastrointestinal problems arising as a result of treatment for cancer (http://tinyurl.com/a6krvl8)

Bifidobacterium and gastrointestinal inflammation

Liam O’Mahony (Swiss Institute of Allergy and Asthma Research) talks to Mairi McLean (senior clinical lecturer and consultant in gastroenterology at the University of Aberdeen) about his paper looking at Bifidobacterium infantis’s interaction with T cells, and the bacterium’s potential to protect against gastrointestinal inflammation.See also:Bifidobacterium infantis 35624 administration induces Foxp3 T regulatory cells in human peripheral blood: potential role for myeloid and plasmacytoid dendritic cells (http://tinyurl.com/b6xnnsx)

High-fat diet and gut microbiota

Mairi Mclean, Gut’s education editor, talks to Matteo Serino from the Institut National de la Santé et de la Recherche Médicale (INSERM), about his article Metabolic adaptation to a high-fat diet is associated with a change in the gut microbiota (http://tinyurl.com/a4rdl2e), which is this month’s editor’s choice.

Management of Helicobacter pylori infection

Gut education editor Mairi Mclean talks to Professor Peter Malfertheiner, from the European Helicobacter Study Group, about the May editor’s choice paper: Management of Helicobacter pylori infection—the Maastricht IV/ Florence Consensus Report.See also:Guidelines: Management of Helicobacter pylori infection—the Maastricht IV/ Florence Consensus Report (http://tinyurl.com/bj2zn2g)

Assessment of colorectal cancer molecular features

Gut education editor Mairi Mclean talks to Dr Shuji Ogino, from Harvard Medical School, about his paper on the asessment of colorectal cancer molecular features.See also:Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum (http://tinyurl.com/bgs7o7u)