Gut Podcast

British Society of Gastroenterology guidance for management of IBD during the Covid-19 pandemic

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital, interviews Dr Cathryn Edwards, BSG President and Consultant Gastroenterologist at Torbay Hospital, Devon and Dr Nick Kennedy, Consultant Gastroenterologist, Royal Devon and Exeter NHS Foundation Trust on the British Society of Gastroenterology response to the coronavirus pandemic and on the guidance produced by a team of UK IBD Specialists entitled ‘BSG guidance for management of IBD during the COVID-19 pandemic’ to be published in paper copy in Gut in June 2020.
Paper link is: http://dx.doi.org/10.1136/gutjnl-2020-321244
Acknowledgements - BSG Risk stratification Grid for IBD patients on Immunosuppression - huge thanks go to:
- Prof Charlie Lees, BSG Clinical Research Group (CRG) Chair and Lead of the UK IBD COVID-19 working group. Dr Ian Arnott BSG IBD Section Lead. Dr Chris Lamb, Dr Barney Hawthorne, BSG Guidelines Development Group (GDG) 2019, Dr Gareth Jones and Dr Nick Kennedy (IBD GDG and CRG) and 70+ clinical colleagues who contributed to the collaborative discussions through the COVID -19 working group
- The BSG, in particular Dr Cathryn Edwards, the BSG Executive team and BSG Staff
- The IBD Registry Group: Dr Stuart Bloom and Liz Dobson and AIMES who delivered the technical aspects of the IBD Registry web tool
- The Crohn's & Colitis UK team particularly Rukshana Kapasi
BSPGHAN, particularly Prof Richard Russell, Dr Richard Hansen BSPGHAN President Sue Protheroe and Prof Mark Beattie, Editor of Frontline Gastroenterology
- Donal Donoghue Registrar RCP London and Medical Specialty Colleagues
The many patients whose feedback helped improve the IBD Registry COVID-19 tool and the BSG guidance
- The RCN

Global patterns and trends in colorectal cancer incidence in young adults

Dr Philip Smith, Digital and Education Editor of Gut and Consultant Gastroenterologist at the Royal Liverpool Hospital interviews Ms Rebecca Siegel, Scientific Director of Surveillance Research at the American Cancer Society. Ms Rebecca Siegel is first author on the paper 'Global patterns and trends in colorectal cancer incidence in young adults' published in Gut in December 2019.
Read the article - https://gut.bmj.com/content/68/12/2179

Guidelines on the management of inflammatory bowel disease in adults

Dr Christopher Lamb, Clinical Intermediate Fellow at Newcastle University and Honorary Consultant in Gastroenterology at the Newcastle upon Tyne Hospitals NHS Foundation Trust discusses the BSG guidelines on the management of inflammatory bowel disease in adults with Associate Editor of GUT Dr Philip Smith.
Read the article: https://gut.bmj.com/content/68/Suppl_3/s1

European evidence-based guidelines on pancreatic cystic neoplasms

Evidence-based guidelines on the management of pancreatic cystic neoplasms (PCN) are lacking. The guideline discussed in this podcast is a joint initiative of the European Study Group on Cystic Tumours of the Pancreas, United European Gastroenterology, European Pancreatic Club, European-African Hepato-Pancreato-Biliary Association, European Digestive Surgery, and the European Society of Gastrointestinal Endoscopy.
Listen to the discussion between the Education Editor of Gut, Mairi McLean, and Marco del Chiaro, from The European Study Group on Cystic Tumours of the Pancreas. And read the details of the guidelines on the Gut website: https://gut.bmj.com/content/67/5/789.

Viral transfer during FMT linked to better outcomes in recurrent C. diff bacterial infections

Clostridium difficile (C. difficile, C. diff or CDI) is a bacterium associated with the intake of antibiotics which causes diarrhoea. It is easily spread to others, both in hospital and a household environments.
C. Diff infections are generally treated with antibiotics. Recurrent infection is successfully treated with faecal microbiota transplantation (FMT), however the underlying mechanism of action is not well defined. This study identified a key role of the virome within the transferred stool on treatment responses.
Listen to the discussion between the Education Editor of Gut, Mairi McLean, and Siew Ng (The Chinese University of Hong Kong, China), who's the leading author of the Open Access paper “Bacteriophage transfer during faecal microbiota transplantation in Clostridium difficile infection is associated with treatment outcome”, included in the April 2018’s Gut issue (gut.bmj.com/content/67/4/634).

Colorectal cancer: research prioritisation needed in third most lethal malignancy worldwide

Prioritising research and funding could have a significant impact on reducing colorectal cancer disease burden over the next 5 years. The conclusions are included in a study recently published by Gut titled “Critical research gaps and recommendations to inform research prioritisation for more effective prevention and improved outcomes in colorectal cancer” and expanded in this podcast.
In conversation with the journal’s Education Editor Mairi McLean, the leading author of the study, Mark Lawler, identifies 15 critical research gaps which prioritisation and resolution could improve patient outcomes.
Professor Mark Lawler works at the Centre for Cancer Research and Cell Biology, Queen’s University Belfast, UK.
For more details on this Open Access article included in the January 2018 issue of Gut, visit http://gut.bmj.com/content/67/1/179.

Development of an FGF19-based chimeric molecule to promote fatty liver regeneration

In this episode Mairi McLean, Associate Editor of Gut journal, talks to Matias Avila and Carmen Berasai, University of Navarra, Pamplona, Spain. They discuss their published paper "Fibroblast growth factor 15/19 (FGF15/19) protects from diet-induced hepatic steatosis: development of an FGF19-based chimeric molecule to promote fatty liver regeneration".
Full article >> http://gut.bmj.com/content/66/10/1818.info

Feeding the microbiota: transducer of nutrient signals for the host

In this episode Mairi McLean, Associate Editor of Gut journal, talks to Fergus Shanahan, Professor and Chair of the Department of Medicine at University College Cork. They discuss his recent paper in Gut entitled "Feeding the microbiota: transducer of nutrient signals for the host"
Full text - http://gut.bmj.com/content/early/2017/06/29/gutjnl-2017-313872

Dietary emulsifiers directly alter human microbiota composition

In this episode Mairi McLean, Associate Editor of Gut journal, talks to Benoit Chassaing, Georgia State University - Center for Inflammation, Immunity and Infection, about his recently published paper "Dietary emulsifiers directly alter human microbiota composition and gene expression ex vivo potentiating intestinal inflammation".
Full paper>> http://gut.bmj.com/content/66/8/1414

Faecal microbiota transplantation in clinical practice

In this episode Mairi McLean, Associate Editor of Gut journal, talks to Giovanni Cammarota and Gianluca Ianiro from the Agostino Gemelli University. They discuss the April editors choice paper "European consensus conference on faecal microbiota transplantation in clinical practice".
Full paper >> http://gut.bmj.com/content/early/2017/01/13/gutjnl-2016-313017